Dr. Barbara Kaplan, PhD

Publications

Journal Article

• Protecting Human and Animal Health: The Road From Animal Models to New Approach Methods. Pharmacol Rev. 2024
• Age-dependent Effects of Transgenic 2D2 Mice Used to Induce Passive EAE in C57BL/6 Mice. Neuroimmunomodulation. 2023
• Canine Immune Cells Express High Levels of CB1 and CB2 Cannabinoid Receptors and Cannabinoid-Mediated Alteration of Canine Cytokine Production is Vehicle-Dependent. Vet Immunol Immunopathol. 2023
• Cnr1 Knockout has Minimal Impact on Chlorpyrifos-mediated Effects in the Mouse Endocannabinoid System, but it Does Alter Lipopolysaccharide-induced Cytokine Levels in Splenocytes. Chemico-Biological Interactions. 2023
• Environmental Chemical-Sensing AHR Remains an Enigmatic Key Player in Toxicology. Environ Health Perspec. 2023
• Nanochannel Delivery for CBD Therapy: Sustained Low Level Plasma Levels without Liver Toxicity. J Drug Delivery Sci Technol . 2023
• Nanochannel delivery system for CBD: Sustained low level plasma levels without liver toxicity. J Drug Deliv Sci Techno. Page 79. 2023
• Ces1d Inactivation Augments Lung Inflammation in Female Mice. ACS Pharmacol Transl Sci.
• Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification. Environ Health Perspec.
• Potential for TCDD to induce regulatory functions in B cells as part of the mechanism for T cell suppression in EAE. .
• Potential for TCDD to Induce Regulatory Functions in B Cells as Part of the Mechanism for T Cell Suppression in EAE. Toxicol Appl Pharmacol. 2022
• TCDD Inhibition of IgG1 Production in Experimental Autoimmune Encephalomyelitis (EAE) and In Vitro.. Antibodies. 2022
• Nanochannel Delivery for CBD Therapy: Sustained Low Level Plasma Levels without Liver Toxicity. . J Drug Delivery Sci Technol.
• The Enigmatic Role of the Aryl Hydrocarbon Receptor in Immune Modulation: Some Progress but More Questions. Front Toxicol. 2022
• Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts. Front Pharmacol. 2022
• Isolation of Transcriptomic-Quality Total RNA from Mouse Spinal Cords. Current Protocols in Neuroscience. 2022
• Immunomodulation by cannabinoids: Current uses, mechanisms, and identification of data gaps to be addressed for additional therapeutic application. Adv Pharmacol. Volume 91, Pages 1-59. 2021
• The CB 1 Receptor Differentially Regulates IFN-γ Production In Vitro and in Experimental Autoimmune Encephalomyelitis. Cannabis Cannabinoid Res. Volume 6, Issue 4, Pages 300-314. 2021
• Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice. Chem Res Toxicol. Volume 34, Issue 6, Pages 1556-1571. 2021
• TCDD attenuates EAE through induction of FasL on B cells and inhibition of IgG production.. Toxicology. Volume 448, Page 152646. 2021
• Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model.. International journal of molecular sciences. Volume 21, Issue 17. 2020
• CBD Suppression of EAE Is Correlated with Early Inhibition of Splenic IFN-γ + CD8+ T Cells and Modest Inhibition of Neuroinflammation.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2020
• Immune Responses Regulated by Cannabidiol.. Cannabis and cannabinoid research. Volume 5, Issue 1, Pages 12-31. 2020
• Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling.. Environmental toxicology. Volume 34, Issue 10, Pages 1149-1159. 2019
• Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.. Neuroimmunomodulation. Volume 26, Issue 4, Pages 198-207. 2019
• Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions.. Molecules (Basel, Switzerland). Volume 23, Issue 12. 2018
• CLARITY-BPA: Effects of chronic Bisphenol A exposure on the immune system: Part 1 - Quantification of the relative number and proportion of leukocyte populations in the spleen and thymus.. Toxicology. Volume 396-397, Pages 46-53. 2018
• CLARITY-BPA: Effects of chronic bisphenol A exposure on the immune system: Part 2 - Characterization of lymphoproliferative and immune effector responses by splenic leukocytes.. Toxicology. Volume 396-397, Pages 54-67. 2018
• Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis.. Current protocols in toxicology. Volume 75, Pages 11.25.1-11.25.22. 2018
• Induction of Immunosuppressive CD8⁺CD25⁺FOXP3⁺ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.. Journal of immunology (Baltimore, Md. : 1950). Volume 200, Issue 2, Pages 669-680. 2018
• Effect of repeated juvenile exposure to Δ9‑tetrahydrocannabinol on anxiety-related behavior and social interactions in adolescent rats.. Neurotoxicology and teratology. Volume 69, Pages 11-20. 2018
• Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice.. Environmental toxicology. Volume 32, Issue 4, Pages 1399-1411. 2017
• Cannabidiol (CBD) induces functional Tregs in response to low-level T cell activation.. Cellular immunology. Volume 312, Pages 25-34. 2017
• Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB₁ and CB₂ Cannabinoid Receptors.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 11, Issue 4, Pages 669-679. 2016
• Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).. Toxicology. Volume 368-369, Pages 172-182. 2016
• Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 151, Issue 1, Pages 35-43. 2016
• Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation.. Prostaglandins & other lipid mediators. Volume 121, Issue Pt B, Pages 199-206. 2015
• Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 145, Issue 2, Pages 214-32. 2015
• Modulation of HIVGP120 Antigen-Specific Immune Responses In Vivo by Δ9-Tetrahydrocannabinol.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 10, Issue 2, Pages 344-55. 2015
• Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 9, Issue 4, Pages 544-57. 2014
• Induced T cell cytokine production is enhanced by engineered nanoparticles.. Nanotoxicology. Volume 8 Suppl 1, Pages 11-23. 2014
• Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ(9)-tetrahydrocannabinol in human CD4(+) T cells.. Toxicology and applied pharmacology. Volume 273, Issue 1, Pages 209-18. 2013
• Suppression by Δ(9)-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation.. Toxicology. Volume 310, Pages 84-91. 2013
• Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.. Journal of immunotoxicology. Volume 10, Issue 3, Pages 321-8. 2013
• Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice.. Particle and fibre toxicology. Volume 10, Page 26. 2013
• The role of CB1 in immune modulation by cannabinoids.. Pharmacology & therapeutics. Volume 137, Issue 3, Pages 365-74. 2013
• Δ9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 131, Issue 2, Pages 419-33. 2013
• Differential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 7, Issue 4, Pages 969-80. 2012
• Δ9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 7, Issue 4, Pages 843-55. 2012
• Magnitude of stimulation dictates the cannabinoid-mediated differential T cell response to HIVgp120.. Journal of leukocyte biology. Volume 92, Issue 5, Pages 1093-102. 2012
• 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells.. The Journal of pharmacology and experimental therapeutics. Volume 342, Issue 3, Pages 816-26. 2012
• Comparison of the D2 receptor regulation and neurotoxicant susceptibility of nigrostriatal dopamine neurons in wild-type and CB1/CB2 receptor knockout mice.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Volume 7, Issue 3, Pages 533-8. 2012
• Suppression of humoral immune responses by 2,3,7,8-tetrachlorodibenzo-p-dioxin intercalated in smectite clay.. Environmental toxicology and chemistry. Volume 30, Issue 12, Pages 2748-55. 2011
• Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection.. Journal of leukocyte biology. Volume 90, Issue 5, Pages 983-95. 2011
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated disruption of the CD40 ligand-induced activation of primary human B cells.. Toxicology and applied pharmacology. Volume 255, Issue 3, Pages 251-60. 2011
• 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma.. Molecular pharmacology. Volume 80, Issue 1, Pages 201-9. 2011
• TCDD adsorbed on silica as a model for TCDD contaminated soils: Evidence for suppression of humoral immunity in mice.. Toxicology. Volume 282, Issue 3, Pages 82-7. 2011
• Induction of the aryl hydrocarbon receptor-responsive genes and modulation of the immunoglobulin M response by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary human B cells.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 118, Issue 1, Pages 86-97. 2010
• The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.. Toxicologic pathology. Volume 38, Issue 3, Pages 382-92. 2010
• Establishment of an immunoglobulin m antibody-forming cell response model for characterizing immunotoxicity in primary human B cells.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 112, Issue 2, Pages 363-73. 2009
• Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol.. Journal of leukocyte biology. Volume 85, Issue 2, Pages 322-9. 2009
• Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol.. Journal of leukocyte biology. Volume 84, Issue 6, Pages 1574-84. 2008
• The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT).. Biochemical pharmacology. Volume 76, Issue 6, Pages 726-37. 2008
• A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells.. Biochemical pharmacology. Volume 76, Issue 3, Pages 353-61. 2008
• Interferon-gamma renders tumors that express low levels of Her-2/neu sensitive to cytotoxic T cells.. Cancer immunology, immunotherapy : CII. Volume 55, Issue 6, Pages 653-62. 2006
• A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity.. Cancer letters. Volume 224, Issue 1, Pages 153-66. 2005
• 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.. Journal of leukocyte biology. Volume 77, Issue 6, Pages 966-74. 2005
• Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide.. Toxicology and applied pharmacology. Volume 205, Issue 2, Pages 107-15. 2005
• Cannabinoids inhibit the activation of ERK MAPK in PMA/Io-stimulated mouse splenocytes.. International immunopharmacology. Volume 3, Issue 10-11, Pages 1503-10. 2003
• Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes.. The Journal of pharmacology and experimental therapeutics. Volume 306, Issue 3, Pages 1077-85. 2003
• Redirecting T lymphocyte specificity using T cell receptor genes.. International reviews of immunology. Volume 22, Issue 3-4, Pages 229-53. 2003
• Modulation of CREB and NF-kappaB signal transduction by cannabinol in activated thymocytes.. Cellular signalling. Volume 13, Issue 4, Pages 241-50. 2001
• AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun.. Journal of leukocyte biology. Volume 67, Issue 2, Pages 259-66. 2000

comment, editorial

• Endocannabinoid engagement of CB₂ regulates RSV-induced immunity.. Virulence. Volume 9, Issue 1, Pages 494-495. 2018

Presentations

Oral Presentation

• "NAMs and In Vitro Assays for Immunotoxicity with Focus on the IL-2 Luc Assay." Center for Research on Ingredient Safety Annual Meeting, Michigan State University, East Lansing, MI. 2023
• "The Other Project in the Kaplan Lab: TCDD Induces Regulatory B Cells to Suppress Autoimmune Disease." CVM 8011 Graduate seminar series, Mississippi State University, Starkville, MS. 2022
• "Insights Regarding CBD’s Immune Suppressive Effects Obtained from Murine and Canine Cells." Human Toxicology seminar series, University of Iowa, virtual. 2022
• "Pursuing Research with Integrity on Controversial Topics: Marijuana in the Immune System." Faculty United for Toxicology Undergraduate Recruitment and Education Committee, Society of Toxciology, virtual. 2022
• "Research Opportunities at MSU-CVM." MSU Pre-Vet Club Meeting, MSU, Starkville. 2021
• "Inhibition of Peripheral Immune Function and Neuroinflammation by CBD in EAE. ." Center for Research on Ingredient Safety at Michigan State University 2020 Science Symposium, Center for Research on Ingredient Safety at Michigan State University , East Lansing MI (virtual). 2020
• "A Reanalysis: CBD-Treated Human Neuroblastoma Cells Reveal Potential Mediators in Understanding the Anti-Inflammatory and Neuroprotective Mechanisms.." CVM Research Day, College of Veterinary Medicine, Mississippi State University, College of Veterinary Medicine. 2020

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